Prefemin® – Ze 440

Prefemin® – Ze 440

Prefemin® – Ze 440

For the treatment of premenstrual syndrome (PMS) and menstrual cycle disorders.

  • No.1 PMS treatment in Switzerland
  • For physical and mental symptoms
  • “Well-established use” status

This is an authorised medicinal product.

Max Zeller Söhne AG, 8590 Romanshorn

Product information

For the treatment of premenstrual syndrome (PMS), including physical and psychological symptoms such as headaches, skin problems, breast tension, abdominal complaints, mood swings, irritability, nervous tension, depressive mood, fatigue and sleep disturbances.
Traditionally also for the treatment of disturbances of the menstrual cycle.

20 mg dry extract Ze 440 from Vitex agnus-castus L. fruit

Drug-extract-ratio (DER): 6-12:1

Extraction solvent: 60% ethanol (m/m)

1 film-coated tablet per day.

Recommended for minimum 3 months.

Clinical Evidence & Mode of action

The information contained in this section is intended for healthcare professionals only.

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Get in Touch

Max Zeller Soehne AG Seeblickstr. 4 8590 Romanshorn Switzerland

P: +41 71 466 05 00

Ze 440 – The Difference

Best in Class – Ze 440 is the only Vitex agnus-castus extract classified as “well-established use” by Herbal Monograph Products Committee (HMPC) of European Medicines Agency (EMA)

First-line therapy - Proposed by doctors in various guidelines as first-line treatment for PMS

Proven clinical efficacy – A number of placebo-controlled and observational studies prove the efficacy of Ze 440 in PMS treatment

Unique treatment – Causal treatment with Ze 440 instead of symptom alleviation with analgesics, hormones or SSRIs

Optimal dosage – 20 mg Ze 440 is the ideal dosage as shown in clinical study

Excellent safety – Ze 440 is non-hormonal and analgesic free

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Our phyto-pharmaceuticals have proven efficacy, tolerability and safety in numerous clinical trials performed by Zeller and published in peer-reviewed journals.


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