Prefemin® – Ze 440
For the treatment of premenstrual syndrome (PMS), including physical and psychological symptoms such as headaches, skin problems, breast tension, abdominal complaints, mood swings, irritability, nervous tension, depressive mood, fatigue and sleep disturbances.
Traditionally also for the treatment of disturbances of the menstrual cycle.
20 mg dry extract Ze 440 from Vitex agnus-castus L. fruit
Drug-extract-ratio (DER): 6-12:1
Extraction solvent: 60% ethanol (m/m)
1 film-coated tablet per day.
Recommended for minimum 3 months.
Clinical Evidence & Mode of action
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Ze 440 – The Difference
Best in Class – Ze 440 is the only Vitex agnus-castus extract classified as “well-established use” by Herbal Monograph Products Committee (HMPC) of European Medicines Agency (EMA)
First-line therapy - Proposed by doctors in various guidelines as first-line treatment for PMS
Proven clinical efficacy – A number of placebo-controlled and observational studies prove the efficacy of Ze 440 in PMS treatment
Unique treatment – Causal treatment with Ze 440 instead of symptom alleviation with analgesics, hormones or SSRIs
Optimal dosage – 20 mg Ze 440 is the ideal dosage as shown in clinical study
Excellent safety – Ze 440 is non-hormonal and analgesic free