Alluna® – Ze 91019
For the treatment of sleep disorders such as difficulties in falling asleep, staying asleep as well as restless sleep (according to WHO ICD10: F51.0 – 51.2).
Alluna®: 250 mg dry extract of Valeriana officinalis L. root & 60 mg dry extract of Humulus lupulus L. strobile (Ze 91019)
Alluna forte®: 500 mg dry extract of Valeriana officinalis L. root & 120 mg dry extract of Humulus lupulus L. strobile (Ze 91019)
Drug-extract ratio (DER) Valeriana officinalis L.: 5-8:1
Drug-extract ratio (DER) Humulus lupuli L.: 7-10:1
Extraction solvent: 45% methanol (m/m)
Alluna®: 2 film-coated tablets per day
Alluna forte®: 1 film-coated tablet per day
Recommended over a period of 4 weeks
Clinical Evidence & Mode of action
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Ze 91019 – The Difference
Dual mode of action - Ze 91019 induces sleep pressure and regulates circadian rhythm through the adenosine and melatonin receptors. Superior to placebo and Valerian mono-therapy.
Excellent Combination – Ze 91019 reduces sleep onset and nightly awakening, increases sleep duration and improves sleep architecture.
Long-term treatment – Natural therapy suitable for long-term intake, also in elderly patients.
High safety – Well-documented safety, with no addiction potential and no risk for cognitive impairment, drowsiness, morning hang-over or drug –drug interactions.